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Titel:

NADPH oxidases as a source of oxidative stress and molecular target in ischemia/reperfusion injury.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Kleikers, PW; Wingler, K; Hermans, JJ; Diebold, I; Altenhöfer, S; Radermacher, KA; Janssen, B; Gorlach, A; Schmidt, HH
Abstract:
Ischemia/reperfusion injury (IRI) is crucial in the pathology of major cardiovascular diseases, such as stroke and myocardial infarction. Paradoxically, both the lack of oxygen during ischemia and the replenishment of oxygen during reperfusion can cause tissue injury. Clinical outcome is also determined by a third, post-reperfusion phase characterized by tissue remodeling and adaptation. Increased levels of reactive oxygen species (ROS) have been suggested to be key players in all three phases....     »
Zeitschriftentitel:
J Mol Med
Jahr:
2012
Band / Volume:
90
Heft / Issue:
12
Seitenangaben Beitrag:
1391-406
Sprache:
eng
Volltext / DOI:
doi:10.1007/s00109-012-0963-3
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23090009
Print-ISSN:
0946-2716
TUM Einrichtung:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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