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Title:

Maternal low-dose estradiol-17? exposure during pregnancy impairs postnatal progeny weight development and body composition.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Werner Fürst, R; Pistek, VL; Kliem, H; Skurk, T; Hauner, H; Meyer, HH; Ulbrich, SE
Abstract:
Endocrine disrupting chemicals with estrogenic activity play an important role as obesogens. However, studies investigating the most potent natural estrogen, estradiol-17? (E2), at low dose are lacking. We examined endocrine and physiological parameters in gilts receiving distinct concentrations of E2 during pregnancy. We then investigated whether adverse effects prevail in progeny due to a potential endocrine disruption. E2 was orally applied to gilts during the entire period of pregnancy. The...     »
Journal title abbreviation:
Toxicol Appl Pharmacol
Year:
2012
Journal volume:
263
Journal issue:
3
Pages contribution:
338-44
Language:
eng
Fulltext / DOI:
doi:10.1016/j.taap.2012.07.006
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22819784
Print-ISSN:
0041-008X
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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