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Title:

Early allo-SCT for AML with a complex aberrant karyotype--results from a prospective pilot study.

Document type:
Clinical Trial; Journal Article; Multicenter Study
Author(s):
Schmid, C; Schleuning, M; Tischer, J; Holler, E; Haude, KH; Braess, J; Haferlach, C; Baurmann, H; Oruzio, D; Hahn, J; Spiekermann, K; Schlimok, G; Schwerdtfeger, R; Buechner, T; Hiddemann, W; Kolb, HJ
Abstract:
In AML, a complex aberrant karyotype is associated with poor response to chemotherapy and dismal prognosis. We prospectively studied the concept of allogeneic haematopoietic SCT (HSCT), performed early and regardless of response to induction treatment in patients with complex karyotype AML (CK-AML). The preparative regimen consisted of fludarabine, Ara-C and amsacrine (FLAMSA) chemotherapy, followed by reduced intensity conditioning (RIC) 3 days later. In vivo T-cell depletion by anti-thymocyte...     »
Journal title abbreviation:
Bone Marrow Transplant
Year:
2012
Journal volume:
47
Journal issue:
1
Pages contribution:
46-53
Language:
eng
Fulltext / DOI:
doi:10.1038/bmt.2011.15
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21358688
Print-ISSN:
0268-3369
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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