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Title:

Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Illert, AL; Zech, M; Moll, C; Albers, C; Kreutmair, S; Peschel, C; Bassermann, F; Duyster, J
Abstract:
NIPA is an F-box-like protein that contributes to the timing of mitotic entry. It targets nuclear cyclin B1 for ubiquitination in interphase, whereas in G(2)/M phase, NIPA is inactivated by phosphorylation to allow for cyclin B1 accumulation, a critical event for proper G(2)/M transition. We recently specified three serine residues of NIPA and demonstrated a sequential phosphorylation at G(2)/M, where initial Ser-354 and Ser-359 phosphorylation is most crucial for SCF(NIPA) inactivation. In this...     »
Journal title abbreviation:
J Biol Chem
Year:
2012
Journal volume:
287
Journal issue:
45
Pages contribution:
37997-8005
Language:
eng
Fulltext / DOI:
doi:10.1074/jbc.M112.373464
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22955283
Print-ISSN:
0021-9258
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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