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Title:

Fas death receptor signalling: roles of Bid and XIAP.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
Author(s):
Kaufmann, T; Strasser, A; Jost, PJ
Abstract:
Fas (also called CD95 or APO-1), a member of a subgroup of the tumour necrosis factor receptor superfamily that contain an intracellular death domain, can initiate apoptosis signalling and has a critical role in the regulation of the immune system. Fas-induced apoptosis requires recruitment and activation of the initiator caspase, caspase-8 (in humans also caspase-10), within the death-inducing signalling complex. In so-called type 1 cells, proteolytic activation of effector caspases (-3 and -7)...     »
Journal title abbreviation:
Cell Death Differ
Year:
2012
Journal volume:
19
Journal issue:
1
Pages contribution:
42-50
Language:
eng
Fulltext / DOI:
doi:10.1038/cdd.2011.121
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21959933
Print-ISSN:
1350-9047
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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