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Titel:

The cytotoxicity of anti-CD22 immunotoxin is enhanced by bryostatin 1 in B-cell lymphomas through CD22 upregulation and PKC-?II depletion.

Dokumenttyp:
Journal Article; Article
Autor(en):
Biberacher, V; Decker, T; Oelsner, M; Wagner, M; Bogner, C; Schmidt, B; Kreitman, RJ; Peschel, C; Pastan, I; Meyer Zum Büschenfelde, C; Ringshausen, I
Abstract:
Background In spite of potent first-line therapies for chronic lymphocytic leukemia, treatment remains palliative and all patients frequently relapse. Treatment options for these patients are more limited. BL22 is a recombinant protein composed of the variable region of a monoclonal antibody that binds to CD22 and of PE38, a truncated Pseudomonas exotoxin. BL22 is a very potent drug already used in patients with hairy cell leukemia, whereas in chronic lymphocytic leukemia its cytotoxicity is lim...     »
Zeitschriftentitel:
Haematologica
Jahr:
2012
Band / Volume:
97
Heft / Issue:
5
Seitenangaben Beitrag:
771-9
Sprache:
eng
Volltext / DOI:
doi:10.3324/haematol.2011.049155
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22180432
Print-ISSN:
0390-6078
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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