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Titel:

Early allo-SCT for AML with a complex aberrant karyotype--results from a prospective pilot study.

Dokumenttyp:
Clinical Trial; Journal Article; Multicenter Study
Autor(en):
Schmid, C; Schleuning, M; Tischer, J; Holler, E; Haude, KH; Braess, J; Haferlach, C; Baurmann, H; Oruzio, D; Hahn, J; Spiekermann, K; Schlimok, G; Schwerdtfeger, R; Buechner, T; Hiddemann, W; Kolb, HJ
Abstract:
In AML, a complex aberrant karyotype is associated with poor response to chemotherapy and dismal prognosis. We prospectively studied the concept of allogeneic haematopoietic SCT (HSCT), performed early and regardless of response to induction treatment in patients with complex karyotype AML (CK-AML). The preparative regimen consisted of fludarabine, Ara-C and amsacrine (FLAMSA) chemotherapy, followed by reduced intensity conditioning (RIC) 3 days later. In vivo T-cell depletion by anti-thymocyte...     »
Zeitschriftentitel:
Bone Marrow Transplant
Jahr:
2012
Band / Volume:
47
Heft / Issue:
1
Seitenangaben Beitrag:
46-53
Sprache:
eng
Volltext / DOI:
doi:10.1038/bmt.2011.15
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21358688
Print-ISSN:
0268-3369
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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