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Titel:

The dynamic range of the human metabolome revealed by challenges.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Krug, S; Kastenmüller, G; Stückler, F; Rist, MJ; Skurk, T; Sailer, M; Raffler, J; Römisch-Margl, W; Adamski, J; Prehn, C; Frank, T; Engel, KH; Hofmann, T; Luy, B; Zimmermann, R; Moritz, F; Schmitt-Kopplin, P; Krumsiek, J; Kremer, W; Huber, F; Oeh, U; Theis, FJ; Szymczak, W; Hauner, H; Suhre, K; Daniel, H
Abstract:
Metabolic challenge protocols, such as the oral glucose tolerance test, can uncover early alterations in metabolism preceding chronic diseases. Nevertheless, most metabolomics data accessible today reflect the fasting state. To analyze the dynamics of the human metabolome in response to environmental stimuli, we submitted 15 young healthy male volunteers to a highly controlled 4 d challenge protocol, including 36 h fasting, oral glucose and lipid tests, liquid test meals, physical exercise, and...     »
Zeitschriftentitel:
FASEB J
Jahr:
2012
Band / Volume:
26
Heft / Issue:
6
Seitenangaben Beitrag:
2607-19
Sprache:
eng
Volltext / DOI:
doi:10.1096/fj.11-198093
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22426117
Print-ISSN:
0892-6638
TUM Einrichtung:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin; III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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