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Titel:

Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Illert, AL; Zech, M; Moll, C; Albers, C; Kreutmair, S; Peschel, C; Bassermann, F; Duyster, J
Abstract:
NIPA is an F-box-like protein that contributes to the timing of mitotic entry. It targets nuclear cyclin B1 for ubiquitination in interphase, whereas in G(2)/M phase, NIPA is inactivated by phosphorylation to allow for cyclin B1 accumulation, a critical event for proper G(2)/M transition. We recently specified three serine residues of NIPA and demonstrated a sequential phosphorylation at G(2)/M, where initial Ser-354 and Ser-359 phosphorylation is most crucial for SCF(NIPA) inactivation. In this...     »
Zeitschriftentitel:
J Biol Chem
Jahr:
2012
Band / Volume:
287
Heft / Issue:
45
Seitenangaben Beitrag:
37997-8005
Sprache:
eng
Volltext / DOI:
doi:10.1074/jbc.M112.373464
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22955283
Print-ISSN:
0021-9258
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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