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Titel:

Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo.

Dokumenttyp:
Journal Article
Autor(en):
Feuerecker, B; Pirsig, S; Seidl, C; Aichler, M; Feuchtinger, A; Bruchelt, G; Senekowitsch-Schmidtke, R
Abstract:
Cancer cells convert glucose preferentially to lactate even in the presence of oxygen (aerobic glycolysis-Warburg effect). New concepts in cancer treatment aim at inhibition of aerobic glycolysis. Pyruvate dehydrogenase converts pyruvate to acetylCoA thus preventing lactate formation. Therefore, the aim of this study was to evaluate compounds that could activate pyruvate dehydrogenase in cancer cells. We investigated the effects of (R)-(+)-?-lipoic acid (LPA) and dichloroacetate (DCA), possible...     »
Zeitschriftentitel:
Cancer Biol Ther
Jahr:
2012
Band / Volume:
13
Heft / Issue:
14
Seitenangaben Beitrag:
1425-35
Sprache:
eng
Volltext / DOI:
doi:10.4161/cbt.22003
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22954700
Print-ISSN:
1538-4047
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin
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