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Titel:

High molecular mass radioimmunoconjugates are promising for intraperitoneal ?-emitter immunotherapy due to prolonged retention in the peritoneum.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Rauch, C; Seidl, C; Schlapschy, M; Skerra, A; Morgenstern, A; Bruchertseifer, F; Senekowitsch-Schmidtke, R
Abstract:
Therapeutic efficacy of intraperitoneal radioimmunotherapy is dependent on the time of retention of the radioimmunoconjugates within the peritoneal cavity. Therefore, the aim of this study was to investigate intraperitoneal retention of Fab, IgG and IgM radioimmunoconjugates.Female Balb/c mice were injected with 213Bi- or 111In-labeled IgM, IgG and recombinant Fab conjugates intraperitoneally or intravenously. At different time points after injection, whole body distribution of radionuclides was...     »
Zeitschriftentitel:
Nucl Med Biol
Jahr:
2012
Band / Volume:
39
Heft / Issue:
5
Seitenangaben Beitrag:
617-27
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.nucmedbio.2011.12.005
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22381781
Print-ISSN:
0969-8051
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin
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