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Titel:

Thrombin-induced shedding of tumour endothelial marker 5 and exposure of its RGD motif are regulated by cell-surface protein disulfide-isomerase.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Vallon, M; Aubele, P; Janssen, KP; Essler, M
Abstract:
TEM5 (tumour endothelial marker 5; also known as GPR124) is an adhesion G-protein-coupled receptor containing a cryptic RGD motif in its extracellular domain. TEM5 is expressed in endothelial cells and pericytes during angiogenesis. In the present paper, we report that thrombin mediates shedding of an N-terminal TEM5 fragment of 60 kDa (termed N60) containing the RGD motif in an open conformation. Thrombin directly cleaved rsTEM5 (recombinant soluble TEM5) 5 and 34 residues downstream of the RG...     »
Zeitschriftentitel:
Biochem J
Jahr:
2012
Band / Volume:
441
Heft / Issue:
3
Seitenangaben Beitrag:
937-44
Sprache:
eng
Volltext / DOI:
doi:10.1042/BJ20111682
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22013897
Print-ISSN:
0264-6021
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Klinik und Poliklinik für Nuklearmedizin
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