Human leukocyte antigen distribution in German Caucasians with advanced Ewing's sarcoma.

Thiel, U; Wolf, P; Wawer, A; Blaeschke, F; Grunewald, TG; von Lüttichau, IT; Klingebiel, T; Bader, P; Borkhardt, A; Laws, HJ; Handgretinger, R; Lang, P; Schlegel, PG; Eyrich, M; Gruhn, B; Ehninger, G; Koscielniak, E; Klein, C; Sykora, KW; Holler, E; Mauz-Körholz, C; Woessmann, W; Richter, GH; Schmidt, AH; Peters, C; Dirksen, U; Jürgens, H; Bregni, M; Burdach, S

doi:10.1055/s-0032-1321730

2012

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Title:: Human leukocyte antigen distribution in German Caucasians with advanced Ewing's sarcoma.
Document type:: Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):: Thiel, U; Wolf, P; Wawer, A; Blaeschke, F; Grunewald, TG; von Lüttichau, IT; Klingebiel, T; Bader, P; Borkhardt, A; Laws, HJ; Handgretinger, R; Lang, P; Schlegel, PG; Eyrich, M; Gruhn, B; Ehninger, G; Koscielniak, E; Klein, C; Sykora, KW; Holler, E; Mauz-Körholz, C; Woessmann, W; Richter, GH; Schmidt, AH; Peters, C; Dirksen, U; Jürgens, H; Bregni, M; Burdach, S
Abstract:: Risk stratification criteria for patients with Ewing's sarcoma family of tumors (ESFT) are still limited. We hypothesized divergent human leukocyte antigen (HLA) patterns in ESFT patients and compared HLA-A, -B and -DR phenotype frequencies of patients with advanced ESFT with those of healthy controls.HLA types of all German Caucasian patients with advanced ESFT and available HLA-A, -B and -DR data registered in the European Group for Blood and Marrow Transplantation, Paediatric Registry for Stem Cell Transplantation and the MetaEICESS data bases (study group, n=30) were retrospectively compared with HLA types of healthy German stem cell donors (control group, n=8 862 for single HLA frequencies and n=8 839 for allele combinations). Study group patients had been immuno-typed due to eligibility for allogeneic stem cell transplantation for high risk of treatment failure, and thus constituted a selected subgroup of ESFT patients.After Bonferroni correction for multiple testing (PC), phenotype frequencies of HLA-A24 remained significantly higher in the study group compared to controls (PC<0.05). Furthermore, several HLA combinations were significantly more frequent in the study group compared to controls (all PC<0.05).We report an increased incidence of circumscribed HLA patterns in German Caucasians with advanced ESFT. The possible clinical significance of this observation has to be re-assessed in prospective trials comprising larger ESFT patient numbers of all risk groups.
Journal title abbreviation:: Klin Padiatr
Year:: 2012
Journal volume:: 224
Journal issue:: 6
Pages contribution:: 353-8
Language:: eng
Fulltext / DOI:: doi:10.1055/s-0032-1321730
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/22821288
Print-ISSN:: 0300-8630
TUM Institution:: Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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