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Title:

Transforming growth factor ?1 inhibits bone morphogenic protein (BMP)-2 and BMP-7 signaling via upregulation of Ski-related novel protein N (SnoN): possible mechanism for the failure of BMP therapy?

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Ehnert, S; Zhao, J; Pscherer, S; Freude, T; Dooley, S; Kolk, A; Stöckle, U; Nüssler, AK; Hube, R
Abstract:
Bone morphogenic proteins (BMPs) play a key role in bone formation. Consequently, it was expected that topical application of recombinant human (rh)BMP-2 and rhBMP-7 would improve the healing of complex fractures. However, up to 36% of fracture patients do not respond to this therapy. There are hints that a systemic increase in transforming growth factor ?1 (TGF?1) interferes with beneficial BMP effects. Therefore, in the present work we investigated the influence of rhTGF?1 on rhBMP signaling i...     »
Journal title abbreviation:
BMC Med
Year:
2012
Journal volume:
10
Pages contribution:
101
Language:
eng
Fulltext / DOI:
doi:10.1186/1741-7015-10-101
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22958403
Print-ISSN:
1741-7015
TUM Institution:
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie; Klinik und Poliklinik für Unfallchirurgie
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