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Titel:

Bisphosphonate related osteonecrosis of the jaw: A minipig large animal model.

Dokumenttyp:
Journal Article
Autor(en):
Pautke, C; Kreutzer, K; Weitz, J; Knodler, M; Münzel, D; Wexel, G; Otto, S; Hapfelmeier, A; Stürzenbaum, S; Tischer, T
Abstract:
Bisphosphonate related osteonecrosis of the jaw (BRONJ) is rare but potentially severe, and the etiopathology and risk factors are poorly defined. To date, it has not been possible to induce BRONJ in a large animal model, a shortfall this study aims to redress. Ten two-year-old adult Göttingen minipigs were split into two groups. Five pigs (group 1) were administered intravenously a weekly dose of a bisphosphonate (zoledonate 0.05mg/kg body weight, approximating the oncologic dose in humans) and...     »
Zeitschriftentitel:
Bone
Jahr:
2012
Band / Volume:
51
Heft / Issue:
3
Seitenangaben Beitrag:
592-9
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.bone.2012.04.020
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22575441
Print-ISSN:
8756-3282
TUM Einrichtung:
Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
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