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Title:

Increased reprogramming capacity of mouse liver progenitor cells, compared with differentiated liver cells, requires the BAF complex.

Document type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media; Article
Author(s):
Kleger, A; Mahaddalkar, PU; Katz, SF; Lechel, A; Joo, JY; Loya, K; Lin, Q; Hartmann, D; Liebau, S; Kraus, JM; Cantz, T; Kestler, HA; Zaehres, H; Schöler, H; Rudolph, KL
Abstract:
Ectopic expression of certain transcription factors can reprogram somatic cells to a pluripotent state. Hematopoietic and muscle stem cells can be more efficiently reprogrammed than differentiated blood or muscle cells, yet similar findings have not been shown in other primary organ systems. Moreover, molecular characteristics of the cellular hierarchy of tissues that influence reprogramming capacities need to be delineated. We analyzed the effect of differentiation stage of freshly isolated, mo...     »
Journal title abbreviation:
Gastroenterology
Year:
2012
Journal volume:
142
Journal issue:
4
Pages contribution:
907-17
Language:
eng
Fulltext / DOI:
doi:10.1053/j.gastro.2012.01.004
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22245845
Print-ISSN:
0016-5085
TUM Institution:
Chirurgische Klinik und Poliklinik
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