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Title:

A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Wang, J; Sun, Q; Morita, Y; Jiang, H; Gross, A; Lechel, A; Hildner, K; Guachalla, LM; Gompf, A; Hartmann, D; Schambach, A; Wuestefeld, T; Dauch, D; Schrezenmeier, H; Hofmann, WK; Nakauchi, H; Ju, Z; Kestler, HA; Zender, L; Rudolph, KL
Abstract:
Checkpoints that limit stem cell self-renewal in response to DNA damage can contribute to cancer protection but may also promote tissue aging. Molecular components that control stem cell responses to DNA damage remain to be delineated. Using in vivo RNAi screens, we identified basic leucine zipper transcription factor, ATF-like (BATF) as a major component limiting self-renewal of hematopoietic stem cells (HSCs) in response to telomere dysfunction and ?-irradiation. DNA damage induces BATF in a G...     »
Journal title abbreviation:
Cell
Year:
2012
Journal volume:
148
Journal issue:
5
Pages contribution:
1001-14
Language:
eng
Fulltext / DOI:
doi:10.1016/j.cell.2012.01.040
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22385964
Print-ISSN:
0092-8674
TUM Institution:
Chirurgische Klinik und Poliklinik
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