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Title:

Prolyl hydroxylase-2 (PHD2) exerts tumor-suppressive activity in pancreatic cancer.

Document type:
Journal Article
Author(s):
Su, Y; Loos, M; Giese, N; Metzen, E; Büchler, MW; Friess, H; Kornberg, A; Büchler, P
Abstract:
Pancreatic cancer is 1 of the most common and poorly treated tumors. In search of new therapeutic approaches, the oxygen sensors prolyl hydroxylases (PHD) are potential targets. PHD2 is considered the key oxygen sensor-regulating hypoxia-inducible factor (HIF). Currently, there is conflicting evidence regarding the exact role of PHD2 in tumorigenesis. The objective of this study was to investigate the role of PHD2 in pancreatic cancer growth and progression.PHD2 expression was analyzed by quanti...     »
Journal title abbreviation:
Cancer
Year:
2012
Journal volume:
118
Journal issue:
4
Pages contribution:
960-72
Language:
eng
Fulltext / DOI:
doi:10.1002/cncr.26344
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21792862
Print-ISSN:
0008-543X
TUM Institution:
Chirurgische Klinik und Poliklinik
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