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Titel:

Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic cancer cell phenotype.

Dokumenttyp:
In Vitro; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
De Oliveira, T; Abiatari, I; Raulefs, S; Sauliunaite, D; Erkan, M; Kong, B; Friess, H; Michalski, CW; Kleeff, J
Abstract:
We have identified syndecan-2 as a protein potentially involved in perineural invasion of pancreatic adenocarcinoma (PDAC) cells.Syndecan-2 (SDC-2) expression was analyzed in human normal pancreas, chronic pancreatitis and PDAC tissues. Functional in vitro assays were carried out to determine its role in invasion, migration and signaling.SDC-2 was expressed in the majority of the tested pancreatic cancer cell lines while it was upregulated in nerve-invasive PDAC cell clones. There were 2 distinc...     »
Zeitschriftentitel:
Mol Cancer
Jahr:
2012
Band / Volume:
11
Seitenangaben Beitrag:
19
Sprache:
eng
Volltext / DOI:
doi:10.1186/1476-4598-11-19
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22471946
Print-ISSN:
1476-4598
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
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