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Titel:

A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Wang, J; Sun, Q; Morita, Y; Jiang, H; Gross, A; Lechel, A; Hildner, K; Guachalla, LM; Gompf, A; Hartmann, D; Schambach, A; Wuestefeld, T; Dauch, D; Schrezenmeier, H; Hofmann, WK; Nakauchi, H; Ju, Z; Kestler, HA; Zender, L; Rudolph, KL
Abstract:
Checkpoints that limit stem cell self-renewal in response to DNA damage can contribute to cancer protection but may also promote tissue aging. Molecular components that control stem cell responses to DNA damage remain to be delineated. Using in vivo RNAi screens, we identified basic leucine zipper transcription factor, ATF-like (BATF) as a major component limiting self-renewal of hematopoietic stem cells (HSCs) in response to telomere dysfunction and ?-irradiation. DNA damage induces BATF in a G...     »
Zeitschriftentitel:
Cell
Jahr:
2012
Band / Volume:
148
Heft / Issue:
5
Seitenangaben Beitrag:
1001-14
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.cell.2012.01.040
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22385964
Print-ISSN:
0092-8674
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
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