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- Document type:
- Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
- Author(s):
- Nickel, T; Vogeser, M; Emslander, I; David, R; Heilmeier, B; Op den Winkel, M; Schmidt-Trucksäss, A; Wilbert-Lampen, U; Hanssen, H; Halle, M
- Title:
- Extreme exercise enhances chromogranin A levels correlating with stress levels but not with cardiac burden.
- Abstract:
- Stress and heart failure are associated with increased systemic levels of chromogranin A (CGA). Here we analyzed the effects of marathon running on systemic CGA levels and the association with cardiac burden and stress.We recruited 47 lean and obese runners for a 10week training program aiming at running a marathon. Heart rates, individual fitness and marathon finishing times were monitored. CGA, proBNP and troponin T levels were analyzed by ELISA.We found a significant increase of CGA (+51%; p<0.01) in lean runners after marathon. The obese group showed the highest troponin T (0.22ng/ml; p<0.01) and proBNP (176.6ng/ml; p<0.01) levels. There were no correlations between proBNP, troponin T and CGA. An inverse correlation (r=-0.45; p<0.01) was found between CGA and finishing times.Marathon running is associated with increased CGA levels. However, this does not seem to reflect cardiac burden but rather marathon induced stress.
- Journal title abbreviation:
- Atherosclerosis
- Year:
- 2012
- Journal volume:
- 220
- Journal issue:
- 1
- Pages contribution:
- 219-22
- Language:
- eng
- Fulltext / DOI:
- doi:10.1016/j.atherosclerosis.2011.09.036
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/22035982
- Print-ISSN:
- 0021-9150
- TUM Institution:
- Poliklinik für Präventive und Rehabilitative Sportmedizin
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