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Title:

Mechanical properties and in vitro behavior of nanofiber-hydrogel composites for tissue engineering applications

Author(s):
Kai, D., Prabhakaran, M. P., Stahl, B., Eblenkamp, M., Wintermantel, E., Ramakrishna, S.
Abstract:
Hydrogel-based biomaterial systems have great potential for tissue reconstruction by serving as temporary scaffolds and cell delivery vehicles for tissue engineering (TE). Hydrogels have poor mechanical properties and their rapid degradation limits the development and application of hydrogels in TE. In this study, nanofiber reinforced composite hydrogels were fabricated by incorporating electrospun poly(epsilon-caprolactone) (PCL)/gelatin 'blend' or 'coaxial' nanofibers into gelatin hydrogels. T...     »
Keywords:
Cell Proliferation Cell Survival Cells, Cultured Compressive Strength Elastic Modulus Equipment Design Equipment Failure Analysis Gelatin/*chemistry Humans Hydrogels/chemistry Materials Testing Mesenchymal Stromal Cells/*cytology/*physiology Nanostructures/*chemistry/ultrastructure Particle Size Polyesters/*chemistry Tissue Engineering/*instrumentation/methods *Tissue Scaffolds
Journal title:
Nanotechnology
Year:
2012
Journal volume:
23
Journal issue:
9
Pages contribution:
095705
Covered by:
Web of Science
Reviewed:
ja
Fulltext / DOI:
doi:10.1088/0957-4484/23/9/095705
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