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Titel:

Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons.

Dokumenttyp:
Journal Article
Autor(en):
Berland, Chloé; Montalban, Enrica; Perrin, Elodie; Di Miceli, Mathieu; Nakamura, Yuko; Martinat, Maud; Sullivan, Mary; Davis, Xue S; Shenasa, Mohammad Ali; Martin, Claire; Tolu, Stefania; Marti, Fabio; Caille, Stephanie; Castel, Julien; Perez, Sylvie; Salinas, Casper Gravesen; Morel, Chloé; Hecksher-Sørensen, Jacob; Cador, Martine; Fioramonti, Xavier; Tschöp, Matthias H; Layé, Sophie; Venance, Laurent; Faure, Philippe; Hnasko, Thomas S; Small, Dana M; Gangarossa, Giuseppe; Luquet, Serge H
Abstract:
Energy-dense food alters dopaminergic (DA) transmission in the mesocorticolimbic (MCL) system and can promote reward dysfunctions, compulsive feeding, and weight gain. Yet the mechanisms by which nutrients influence the MCL circuitry remain elusive. Here, we show that nutritional triglycerides (TGs), a conserved post-prandial metabolic signature among mammals, can be metabolized within the MCL system and modulate DA-associated behaviors by gating the activity of dopamine receptor subtype 2 (DRD2...     »
Zeitschriftentitel:
Cell Metab
Jahr:
2020
Band / Volume:
31
Heft / Issue:
4
Seitenangaben Beitrag:
773-790.e11
Volltext / DOI:
doi:10.1016/j.cmet.2020.02.010
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32142669
Print-ISSN:
1550-4131
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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