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Title:

High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Gruber, Tim; Lechner, Franziska; Murat, Cahuê; Contreras, Raian E; Sanchez-Quant, Eva; Miok, Viktorian; Makris, Konstantinos; Le Thuc, Ophélia; González-García, Ismael; García-Clave, Elena; Althammer, Ferdinand; Krabichler, Quirin; DeCamp, Lisa M; Jones, Russell G; Lutter, Dominik; Williams, Rhiannan H; Pfluger, Paul T; Müller, Timo D; Woods, Stephen C; Pospisilik, John Andrew; Martinez-Jimenez, Celia P; Tschöp, Matthias H; Grinevich, Valery; García-Cáceres, Cristina
Abstract:
Oxytocin-expressing paraventricular hypothalamic neurons (PVNOT neurons) integrate afferent signals from the gut, including cholecystokinin (CCK), to adjust whole-body energy homeostasis. However, the molecular underpinnings by which PVNOT neurons orchestrate gut-to-brain feeding control remain unclear. Here, we show that mice undergoing selective ablation of PVNOT neurons fail to reduce food intake in response to CCK and develop hyperphagic obesity on a chow diet. Notably, exposing wild-type mi...     »
Journal title abbreviation:
Cell Rep
Year:
2023
Journal volume:
42
Journal issue:
10
Fulltext / DOI:
doi:10.1016/j.celrep.2023.113305
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37864798
Print-ISSN:
2211-1247
TUM Institution:
602; Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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