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Title:

Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice.

Document type:
Article; Journal Article
Author(s):
Liskiewicz, Arkadiusz; Khalil, Ahmed; Liskiewicz, Daniela; Novikoff, Aaron; Grandl, Gerald; Maity-Kumar, Gandhari; Gutgesell, Robert M; Bakhti, Mostafa; Bastidas-Ponce, Aimée; Czarnecki, Oliver; Makris, Konstantinos; Lickert, Heiko; Feuchtinger, Annette; Tost, Monica; Coupland, Callum; Ständer, Lisa; Akindehin, Seun; Prakash, Sneha; Abrar, Faiyaz; Castelino, Russell L; He, Yantao; Knerr, Patrick J; Yang, Bin; Hogendorf, Wouter F J; Zhang, Shiqi; Hofmann, Susanna M; Finan, Brian; DiMarchi, Richar...     »
Abstract:
The development of single-molecule co-agonists for the glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) is considered a breakthrough in the treatment of obesity and type 2 diabetes. But although GIPR-GLP-1R co-agonism decreases body weight with superior efficacy relative to GLP-1R agonism alone in preclinical1-3 and clinical studies4,5, the role of GIP in regulating energy metabolism remains enigmatic. Increasing evidence su...     »
Journal title abbreviation:
Nat Metab
Year:
2023
Journal volume:
5
Journal issue:
12
Pages contribution:
2075-2085
Fulltext / DOI:
doi:10.1038/s42255-023-00931-7
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37946085
TUM Institution:
602; Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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