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Title:

Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons.

Document type:
Journal Article
Author(s):
Berland, Chloé; Montalban, Enrica; Perrin, Elodie; Di Miceli, Mathieu; Nakamura, Yuko; Martinat, Maud; Sullivan, Mary; Davis, Xue S; Shenasa, Mohammad Ali; Martin, Claire; Tolu, Stefania; Marti, Fabio; Caille, Stephanie; Castel, Julien; Perez, Sylvie; Salinas, Casper Gravesen; Morel, Chloé; Hecksher-Sørensen, Jacob; Cador, Martine; Fioramonti, Xavier; Tschöp, Matthias H; Layé, Sophie; Venance, Laurent; Faure, Philippe; Hnasko, Thomas S; Small, Dana M; Gangarossa, Giuseppe; Luquet, Serge H
Abstract:
Energy-dense food alters dopaminergic (DA) transmission in the mesocorticolimbic (MCL) system and can promote reward dysfunctions, compulsive feeding, and weight gain. Yet the mechanisms by which nutrients influence the MCL circuitry remain elusive. Here, we show that nutritional triglycerides (TGs), a conserved post-prandial metabolic signature among mammals, can be metabolized within the MCL system and modulate DA-associated behaviors by gating the activity of dopamine receptor subtype 2 (DRD2...     »
Journal title abbreviation:
Cell Metab
Year:
2020
Journal volume:
31
Journal issue:
4
Pages contribution:
773-790.e11
Fulltext / DOI:
doi:10.1016/j.cmet.2020.02.010
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32142669
Print-ISSN:
1550-4131
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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