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Title:

A BAFF/APRIL axis regulates obesogenic diet-driven weight gain.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Author(s):
Chan, Calvin C; Harley, Isaac T W; Pfluger, Paul T; Trompette, Aurelien; Stankiewicz, Traci E; Allen, Jessica L; Moreno-Fernandez, Maria E; Damen, Michelle S M A; Oates, Jarren R; Alarcon, Pablo C; Doll, Jessica R; Flick, Matthew J; Flick, Leah M; Sanchez-Gurmaches, Joan; Mukherjee, Rajib; Karns, Rebekah; Helmrath, Michael; Inge, Thomas H; Weisberg, Stuart P; Pamp, Sünje J; Relman, David A; Seeley, Randy J; Tschöp, Matthias H; Karp, Christopher L; Divanovic, Senad
Abstract:
The impact of immune mediators on weight homeostasis remains underdefined. Interrogation of resistance to diet-induced obesity in mice lacking a negative regulator of Toll-like receptor signaling serendipitously uncovered a role for B cell activating factor (BAFF). Here we show that overexpression of BAFF in multiple mouse models associates with protection from weight gain, approximating a log-linear dose response relation to BAFF concentrations. Gene expression analysis of BAFF-stimulated subcu...     »
Journal title abbreviation:
Nat Commun
Year:
2021
Journal volume:
12
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-021-23084-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34006859
Print-ISSN:
2041-1723
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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