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Title:

Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Becker, Maike; Joseph, Sini S; Garcia-Carrizo, Francisco; Tom, Robby Z; Opaleva, Daria; Serr, Isabelle; Tschöp, Matthias H; Schulz, Tim J; Hofmann, Susanna M; Daniel, Carolin
Abstract:
Muscle-residing regulatory T cells (Tregs) control local tissue integrity and function. However, the molecular interface connecting Treg-based regulation with muscle function and regeneration remains largely unexplored. Here, we show that exercise fosters a stable induction of highly functional muscle-residing Tregs with increased expression of amphiregulin (Areg), EGFR, and ST2. Mechanistically, we find that mice lacking IL6Rα on T cells (TKO) harbor significant reductions in muscle Treg functi...     »
Journal title abbreviation:
Cell Metab
Year:
2023
Journal volume:
35
Journal issue:
10
Pages contribution:
1736-1751.e7
Fulltext / DOI:
doi:10.1016/j.cmet.2023.08.010
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37734370
Print-ISSN:
1550-4131
TUM Institution:
602; Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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