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Titel:

Skeletal muscle and intermuscular adipose tissue gene expression profiling identifies new biomarkers with prognostic significance for insulin resistance progression and intervention response.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Lutter, Dominik; Sachs, Stephan; Walter, Marc; Kerege, Anna; Perreault, Leigh; Kahn, Darcy E; Wolide, Amare D; Kleinert, Maximilian; Bergman, Bryan C; Hofmann, Susanna M
Abstract:
AIMS/HYPOTHESIS: Although insulin resistance often leads to type 2 diabetes mellitus, its early stages are often unrecognised, thus reducing the probability of successful prevention and intervention. Moreover, treatment efficacy is affected by the genetics of the individual. We used gene expression profiles from a cross-sectional study to identify potential candidate genes for the prediction of diabetes risk and intervention response. METHODS: Using a multivariate regression model, we linked gen...     »
Zeitschriftentitel:
Diabetologia
Jahr:
2023
Band / Volume:
66
Heft / Issue:
5
Seitenangaben Beitrag:
873-883
Volltext / DOI:
doi:10.1007/s00125-023-05874-y
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36790478
Print-ISSN:
0012-186X
TUM Einrichtung:
602; Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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