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Titel:

Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma.

Dokumenttyp:
Journal Article
Autor(en):
Jian, Ziying; Cheng, Tao; Zhang, Zhiheng; Raulefs, Susanne; Shi, Kuangyu; Steiger, Katja; Maeritz, Nadja; Kleigrewe, Karin; Hofmann, Thomas; Benitz, Simone; Bruns, Philipp; Lamp, Daniel; Jastroch, Martin; Akkan, Jan; Jäger, Carsten; Huang, Peilin; Nie, Shuang; Shen, Shanshan; Zou, Xiaoping; Ceyhan, Güralp O; Michalski, Christoph W; Friess, Helmut; Kleeff, Jörg; Kong, Bo
Abstract:
Although nearly half of pancreatic ductal adenocarcinoma (PDAC) patients have diabetes mellitus with episodes of hyperglycemia, its tumor microenvironment is hypoglycemic. Thus, it is crucial for PDAC cells to develop adaptive mechanisms dealing with oscillating glucose levels. So far, the biological impact of such glycemic variability on PDAC biology remains unknown.Murine PDAC cells were cultured in low- and high-glucose medium to investigate the molecular, biochemical, and metabolic influence...     »
Zeitschriftentitel:
Cell Mol Gastroenterol Hepatol
Jahr:
2018
Band / Volume:
6
Heft / Issue:
4
Seitenangaben Beitrag:
429-449
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jcmgh.2018.07.003
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30258965
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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