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Titel:

Gut hormone co-agonists for the treatment of obesity: from bench to bedside.

Dokumenttyp:
Journal Article; Review
Autor(en):
Nogueiras, Ruben; Nauck, Michael A; Tschöp, Matthias H
Abstract:
The discovery and development of so-called gut hormone co-agonists as a new class of drugs for the treatment of diabetes and obesity is considered a transformative breakthrough in the field. Combining action profiles of multiple gastrointestinal hormones within a single molecule, these novel therapeutics achieve synergistic metabolic benefits. The first such compound, reported in 2009, was based on balanced co-agonism at glucagon and glucagon-like peptide-1 (GLP-1) receptors. Today, several clas...     »
Zeitschriftentitel:
Nat Metab
Jahr:
2023
Band / Volume:
5
Heft / Issue:
6
Seitenangaben Beitrag:
933-944
Volltext / DOI:
doi:10.1038/s42255-023-00812-z
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37308724
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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