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Titel:

Streptozotocin-induced ?-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain.

Dokumenttyp:
Journal Article
Autor(en):
Nikolakopoulou, Polyxeni; Chatzigeorgiou, Antonios; Kourtzelis, Ioannis; Toutouna, Louiza; Masjkur, Jimmy; Arps-Forker, Carina; Poser, Steven W; Rozman, Jan; Rathkolb, Birgit; Aguilar-Pimentel, Juan Antonio; Wolf, Eckhard; Klingenspor, Martin; Ollert, Markus; Schmidt-Weber, Carsten; Fuchs, Helmut; Gailus-Durner, Valerie; Hrabé de Angelis, Martin; Tsata, Vasiliki; Monasor, Laura Sebastian; Troullinaki, Maria; Witt, Anke; Anastasiou, Vivian; Chrousos, George; Yi, Chun-Xia; García-Cáceres, Cristina...     »
Abstract:
Diabetes mellitus is a group of disorders characterized by prolonged high levels of circulating blood glucose. Type 1 diabetes is caused by decreased insulin production in the pancreas whereas type 2 diabetes may develop due to obesity and lack of exercise; it begins with insulin resistance whereby cells fail to respond properly to insulin and it may also progress to decreased insulin levels. The brain is an important target for insulin, and there is great interest in understanding how diabetes...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2018
Band / Volume:
8
Heft / Issue:
1
Seitenangaben Beitrag:
11335
Sprache:
eng
Volltext / DOI:
doi:10.1038/s41598-018-29434-2
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30054579
Print-ISSN:
2045-2322
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp); Molekulare Allergologie (Prof. Schmidt-Weber)
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