Benutzer: Gast  Login
Titel:

Plasma proteome profiles treatment efficacy of incretin dual agonism in diet-induced obese female and male mice.

Dokumenttyp:
Journal Article
Autor(en):
Sachs, Stephan; Niu, Lili; Geyer, Philipp; Jall, Sigrid; Kleinert, Maximilian; Feuchtinger, Annette; Stemmer, Kerstin; Brielmeier, Markus; Finan, Brian; DiMarchi, Richard D; Tschöp, Matthias H; Albrechtsen, Nicolai Wewer; Mann, Matthias; Müller, Timo D; Hofmann, Susanna M
Abstract:
AIMS: Unimolecular peptides targeting the receptors for glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) (GLP-1/GIP co-agonist) have been shown to outperform each single peptide in the treatment of obesity and cardiometabolic disease in preclinical and clinical trials. By combining physiological treatment endpoints with plasma proteomic profiling (PPP), we aimed to identify biomarkers to advance non-invasive metabolic monitoring of compound treatment success...     »
Zeitschriftentitel:
Diabetes Obes Metab
Jahr:
2021
Band / Volume:
23
Heft / Issue:
1
Seitenangaben Beitrag:
195-207
Volltext / DOI:
doi:10.1111/dom.14215
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33001570
Print-ISSN:
1462-8902
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
 BibTeX