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Title:

Pharmacological estrogen administration causes a FSH-independent osteo-anabolic effect requiring ER alpha in osteoblasts.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Seitz, S; Keller, J; Schilling, AF; Jeschke, A; Marshall, RP; Stride, BD; Wintermantel, T; Beil, FT; Amling, M; Schütz, G; Tuckermann, J; Schinke, T
Abstract:
Postmenopausal osteoporosis is characterized by declining estrogen levels, and estrogen replacement therapy has been proven beneficial for preventing bone loss in affected women. While the physiological functions of estrogen in bone, primarily the inhibition of bone resorption, have been studied extensively, the effects of pharmacological estrogen administration are still poorly characterized. Since elevated levels of follicle-stimulating hormone (FSH) have been suggested to be involved in postm...     »
Journal title abbreviation:
PLoS ONE
Year:
2012
Journal volume:
7
Journal issue:
11
Pages contribution:
e50301
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0050301
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23209701
Print-ISSN:
1932-6203
TUM Institution:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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