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Titel:

TNF-alpha induced NF?B signaling and p65 (RelA) overexpression repress Cldn5 promoter in mouse brain endothelial cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Aslam, M; Ahmad, N; Srivastava, R; Hemmer, B
Abstract:
Inflammatory cytokine TNF? enhances permeability of brain capillaries constituting blood brain barrier (BBB). In the monoculture endothelial models of BBB TNF? alters tight junction (TJ) structure and protein content. Claudin-5 (Cldn5) is a key TJ protein whose expression in the brain endothelial cells is critical to the function of BBB. TNF? reduces Cldn5 promoter activity and mRNA expression in mouse brain derived endothelial cells but the regulatory elements and signaling mechanism involved a...     »
Zeitschriftentitel:
Cytokine
Jahr:
2012
Band / Volume:
57
Heft / Issue:
2
Seitenangaben Beitrag:
269-75
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.cyto.2011.10.016
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22138107
Print-ISSN:
1043-4666
TUM Einrichtung:
Neurologische Klinik und Poliklinik
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