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Title:

No association of ABCB1 C3435T genotype with clopidogrel response or risk of stent thrombosis in patients undergoing coronary stenting.

Document type:
Journal Article; Article
Author(s):
Jaitner, J; Morath, T; Byrne, RA; Braun, S; Gebhard, D; Bernlochner, I; Schulz, S; Mehilli, J; Schömig, A; Koch, W; Kastrati, A; Sibbing, D
Abstract:
The prodrug clopidogrel requires intestinal absorption by the efflux pump P-glycoprotein MDR1 (multidrug resistant-1), encoded by the ABCB1 gene. Prior studies suggested that a common and functional genetic variant (C3435T, rs1045642) within ABCB1 influences clopidogrel treatment efficacy; however, existing data are highly inconsistent, because other studies failed to replicate this postulated association. Thus, the aim of this study was to assess the association of ABCB1 C3435T genotypes with...     »
Journal title abbreviation:
Circ Cardiovasc Interv
Year:
2012
Journal volume:
5
Journal issue:
1
Pages contribution:
82-8, S1-2
Language:
eng
Fulltext / DOI:
doi:10.1161/CIRCINTERVENTIONS.111.965400
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22298798
Print-ISSN:
1941-7640
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!); Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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