User: Guest  Login
More Searchfields
Simple search
Title:

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

Document type:
Article
Author(s):
von Bruehl, Marie-Luis; Stark, Konstantin; Steinhart, Alexander; Chandraratne, Sue; Konrad, Ildiko; Lorenz, Michael; Khandoga, Alexander; Tirniceriu, Anca; Coletti, Raffaele; Koellnberger, Maria; Byrne, RobertA; Laitinen, Iina; Walch, Axel; Brill, Alexander; Pfeiler, Susanne; Manukyan, Davit; Braun, Siegmund; Lange, Philipp; Riegger, Julia; Ware, Jerry; Eckart, Annekathri; Haidari, Selgai; Rudelius, Martina; Schulz, Christian; Echtler, Katrin; Brinkmann, Volker; Schwaiger, Markus; Preissner, Kla...     »
Abstract:
Deep vein thrombosis (DVT) is a major cause of cardiovascular death. The sequence of events that promote DVT remains obscure, largely as a result of the lack of an appropriate rodent model. We describe a novel mouse model of DVT which reproduces a frequent trigger and resembles the time course, histological features, and clinical presentation of DVT in humans. We demonstrate by intravital two-photon and epifluorescence microscopy that blood monocytes and neutrophils crawling along and adhering t...     »
Journal title abbreviation:
J Exp Med
Year:
2012
Journal volume:
209
Journal issue:
4
Pages contribution:
819-835
Language:
eng
Fulltext / DOI:
doi:10.1084/jem.20112322
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22451716
Print-ISSN:
0022-1007
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!); Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert); Klinik und Poliklinik für Nuklearmedizin
 BibTeX