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Title:

Bcl10 links saturated fat overnutrition with hepatocellular NF-kB activation and insulin resistance.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Van Beek, M; Oravecz-Wilson, KI; Delekta, PC; Gu, S; Li, X; Jin, X; Apel, IJ; Konkle, KS; Feng, Y; Teitelbaum, DH; Ruland, J; McAllister-Lucas, LM; Lucas, PC
Abstract:
Excess serum free fatty acids (FFAs) are fundamental to the pathogenesis of insulin resistance. With high-fat feeding, FFAs activate NF-kB in target tissues, initiating negative crosstalk with insulin signaling. However, the mechanisms underlying FFA-dependent NF-kB activation remain unclear. Here, we demonstrate that the saturated FA, palmitate, requires Bcl10 for NF-kB activation in hepatocytes. Uptake of palmitate, metabolism to diacylglycerol, and subsequent activation of protein kinase C (P...     »
Journal title abbreviation:
Cell Rep
Year:
2012
Journal volume:
1
Journal issue:
5
Pages contribution:
444-52
Language:
eng
Fulltext / DOI:
doi:10.1016/j.celrep.2012.04.006
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22708078
Print-ISSN:
2211-1247
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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