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Title:

Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Sankaran, VG; Ludwig, LS; Sicinska, E; Xu, J; Bauer, DE; Eng, JC; Patterson, HC; Metcalf, RA; Natkunam, Y; Orkin, SH; Sicinski, P; Lander, ES; Lodish, HF
Abstract:
Genome-wide association studies (GWASs) have identified a genetic variant of moderate effect size at 6p21.1 associated with erythrocyte traits in humans. We show that this variant affects an erythroid-specific enhancer of CCND3. A Ccnd3 knockout mouse phenocopies these erythroid phenotypes, with a dramatic increase in erythrocyte size and a concomitant decrease in erythrocyte number. By examining human and mouse primary erythroid cells, we demonstrate that the CCND3 gene product cyclin D3 regula...     »
Journal title abbreviation:
Genes Dev
Year:
2012
Journal volume:
26
Journal issue:
18
Pages contribution:
2075-87
Language:
eng
Fulltext / DOI:
doi:10.1101/gad.197020.112
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22929040
Print-ISSN:
0890-9369
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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