User: Guest  Login
More Searchfields
Simple search
Title:

Inflammasome activators induce interleukin-1? secretion via distinct pathways with differential requirement for the protease function of caspase-1.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Gross, O; Yazdi, AS; Thomas, CJ; Masin, M; Heinz, LX; Guarda, G; Quadroni, M; Drexler, SK; Tschopp, J
Abstract:
Through their capacity to sense danger signals and to generate active interleukin-1? (IL-1?), inflammasomes occupy a central role in the inflammatory response. In contrast to IL-1?, little is known about how IL-1? is regulated. We found that all inflammasome activators also induced the secretion of IL-1?, leading to the cosecretion of both IL-1 cytokines. Depending on the type of inflammasome activator, release of IL-1? was inflammasome dependent or independent. Calcium influx induced by the ope...     »
Journal title abbreviation:
Immunity
Year:
2012
Journal volume:
36
Journal issue:
3
Pages contribution:
388-400
Language:
eng
Fulltext / DOI:
doi:10.1016/j.immuni.2012.01.018
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22444631
Print-ISSN:
1074-7613
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
 BibTeX