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Title:

Syk kinase-coupled C-type lectin receptors engage protein kinase C-? to elicit Card9 adaptor-mediated innate immunity.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Strasser, D; Neumann, K; Bergmann, H; Marakalala, MJ; Guler, R; Rojowska, A; Hopfner, KP; Brombacher, F; Urlaub, H; Baier, G; Brown, GD; Leitges, M; Ruland, J
Abstract:
C-type lectin receptors (CLRs) that couple with the kinase Syk are major pattern recognition receptors for the activation of innate immunity and host defense. CLRs recognize fungi and other forms of microbial or sterile danger, and they induce inflammatory responses through the adaptor protein Card9. The mechanisms relaying CLR proximal signals to the core Card9 module are unknown. Here we demonstrated that protein kinase C-? (PKC?) was activated upon Dectin-1-Syk signaling, mediated phosphoryla...     »
Journal title abbreviation:
Immunity
Year:
2012
Journal volume:
36
Journal issue:
1
Pages contribution:
32-42
Language:
eng
Fulltext / DOI:
doi:10.1016/j.immuni.2011.11.015
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22265677
Print-ISSN:
1074-7613
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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