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Title:

RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Abdullah, Z; Schlee, M; Roth, S; Mraheil, MA; Barchet, W; Böttcher, J; Hain, T; Geiger, S; Hayakawa, Y; Fritz, JH; Civril, F; Hopfner, KP; Kurts, C; Ruland, J; Hartmann, G; Chakraborty, T; Knolle, PA
Abstract:
Immunity against infection with Listeria monocytogenes is not achieved from innate immune stimulation by contact with killed but requires viable Listeria gaining access to the cytosol of infected cells. It has remained ill-defined how such immune sensing of live Listeria occurs. Here, we report that efficient cytosolic immune sensing requires access of nucleic acids derived from live Listeria to the cytoplasm of infected cells. We found that Listeria released nucleic acids and that such secreted...     »
Journal title abbreviation:
EMBO J
Year:
2012
Journal volume:
31
Journal issue:
21
Pages contribution:
4153-64
Language:
eng
Fulltext / DOI:
doi:10.1038/emboj.2012.274
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23064150
Print-ISSN:
0261-4189
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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