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Title:

A new strategy for the development of monoclonal antibodies for the determination of human procalcitonin in serum samples.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kremmer, E; Meyer, K; Grässer, FA; Flatley, A; Kösters, M; Luppa, PB; Krämer, PM
Abstract:
Procalcitonin (PCT)-a diagnostic serum parameter for bacterial infection and sepsis-is of great interest in the field of biosensors for point-of-care testing. Its detection needs specific biological recognition elements, such as antibodies. Herein, we describe the development and characterization of rat monoclonal antibodies (mAbs) for PCT, and their application in enzyme-linked immunosorbent assays (ELISAs) for the determination of PCT in patient serum samples. From about 50 mAbs, two mAbs, CAL...     »
Journal title abbreviation:
Anal Bioanal Chem
Year:
2012
Journal volume:
402
Journal issue:
2
Pages contribution:
989-95
Language:
eng
Fulltext / DOI:
doi:10.1007/s00216-011-5475-4
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22006244
Print-ISSN:
1618-2642
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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