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Title:

Adiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism.

Document type:
Journal Article
Author(s):
Liu, Q; Yuan, B; Lo, KA; Patterson, HC; Sun, Y; Lodish, HF
Abstract:
The effects of adiponectin on hepatic glucose and lipid metabolism at transcriptional level are largely unknown. We profiled hepatic gene expression in adiponectin knockout (KO) and wild-type (WT) mice by RNA sequencing. Compared with WT mice, adiponectin KO mice fed a chow diet exhibited decreased mRNA expression of rate-limiting enzymes in several important glucose and lipid metabolic pathways, including glycolysis, tricarboxylic acid cycle, fatty-acid activation and synthesis, triglyceride sy...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2012
Journal volume:
109
Journal issue:
36
Pages contribution:
14568-73
Language:
eng
Fulltext / DOI:
doi:10.1073/pnas.1211611109
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22904186
Print-ISSN:
0027-8424
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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