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Titel:

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Vince, JE; Wong, WW; Gentle, I; Lawlor, KE; Allam, R; O'Reilly, L; Mason, K; Gross, O; Ma, S; Guarda, G; Anderton, H; Castillo, R; Häcker, G; Silke, J; Tschopp, J
Abstract:
Interleukin-1? (IL-1?) is a potent inflammatory cytokine that is usually cleaved and activated by inflammasome-associated caspase-1. To determine whether IL-1? activation is regulated by inhibitor of apoptosis (IAP) proteins, we treated macrophages with an IAP-antagonist "Smac mimetic" compound or genetically deleted the genes that encode the three IAP family members cIAP1, cIAP2, and XIAP. After Toll-like receptor priming, IAP inhibition triggered cleavage of IL-1? that was mediated not only by...     »
Zeitschriftentitel:
Immunity
Jahr:
2012
Band / Volume:
36
Heft / Issue:
2
Seitenangaben Beitrag:
215-27
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.immuni.2012.01.012
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22365665
Print-ISSN:
1074-7613
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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