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Titel:

RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Abdullah, Z; Schlee, M; Roth, S; Mraheil, MA; Barchet, W; Böttcher, J; Hain, T; Geiger, S; Hayakawa, Y; Fritz, JH; Civril, F; Hopfner, KP; Kurts, C; Ruland, J; Hartmann, G; Chakraborty, T; Knolle, PA
Abstract:
Immunity against infection with Listeria monocytogenes is not achieved from innate immune stimulation by contact with killed but requires viable Listeria gaining access to the cytosol of infected cells. It has remained ill-defined how such immune sensing of live Listeria occurs. Here, we report that efficient cytosolic immune sensing requires access of nucleic acids derived from live Listeria to the cytoplasm of infected cells. We found that Listeria released nucleic acids and that such secreted...     »
Zeitschriftentitel:
EMBO J
Jahr:
2012
Band / Volume:
31
Heft / Issue:
21
Seitenangaben Beitrag:
4153-64
Sprache:
eng
Volltext / DOI:
doi:10.1038/emboj.2012.274
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23064150
Print-ISSN:
0261-4189
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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