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Titel:

2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Duncan, GS; Brenner, D; Tusche, MW; Brüstle, A; Knobbe, CB; Elia, AJ; Mock, T; Bray, MR; Krammer, PH; Mak, TW
Abstract:
The endogenous metabolite of estradiol, 2-Methoxyestradiol (2ME2), is an antimitotic and antiangiogenic cancer drug candidate that also exhibits disease-modifying activity in animal models of rheumatoid arthritis (RA). We found that 2ME2 dramatically suppresses development of mouse experimental autoimmune encephalomyelitis (EAE), a rodent model of multiple sclerosis (MS). 2ME2 inhibits in vitro lymphocyte activation, cytokine production, and proliferation in a dose-dependent fashion. 2ME2 treatm...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2012
Band / Volume:
109
Heft / Issue:
51
Seitenangaben Beitrag:
21034-9
Sprache:
eng
Volltext / DOI:
doi:10.1073/pnas.1215558110
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23213242
Print-ISSN:
0027-8424
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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