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Title:

Genetic analyses of heme oxygenase 1 (HMOX1) in different forms of pancreatitis.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Weiß, S; Jesinghaus, M; Kovacs, P; Schleinitz, D; Schober, R; Ruffert, C; Herms, M; Wittenburg, H; Stumvoll, M; Blüher, M; Grützmann, R; Schulz, HU; Keim, V; Mössner, J; Bugert, P; Witt, H; Drenth, JP; Krohn, K; Rosendahl, J
Abstract:
Heme oxygenase 1 (HMOX1) is the rate limiting enzyme in heme degradation and a key regulator of inflammatory processes. In animal models the course of pancreatitis was ameliorated by up-regulation of HMOX1 expression. Additionally, carbon monoxide released during heme breakdown inhibited proliferation of pancreatic stellate cells and might thereby prevent the development of chronic pancreatitis (CP). Transcription of HMOX1 in humans is influenced by a GT-repeat located in the promoter. As such,...     »
Journal title abbreviation:
PLoS ONE
Year:
2012
Journal volume:
7
Journal issue:
5
Pages contribution:
e37981
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0037981
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22666428
Print-ISSN:
1932-6203
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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