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Title:

Combined effects of different interleukin-28B gene variants on the outcome of dual combination therapy in chronic hepatitis C virus type 1 infection.

Document type:
Journal Article; Article
Author(s):
Fischer, J; Bohm, S; Scholz, M; Müller, T; Witt, H; George, J; Sarrazin, C; Susser, S; Schott, E; Suppiah, V; Booth, DR; Stewart, GJ; Van Bömmel, F; Brodzinski, A; Fülöp, B; Migaud, P; Berg, T
Abstract:
In patients with chronic hepatitis C virus (HCV) infection, several variants of the interleukin-28B (IL28B) gene have been shown to correlate significantly with a sustained virologic response (SVR). Recent evidence shows that determination of one single IL28B polymorphism, rs12979860, is sufficient for predicting treatment outcome. We examined whether the combined determination of the IL28B single-nucleotide polymorphisms (SNPs), rs12979860, rs8099917, rs12980275, and rs8103142, might improve th...     »
Journal title abbreviation:
Hepatology
Year:
2012
Journal volume:
55
Journal issue:
6
Pages contribution:
1700-10
Language:
eng
Fulltext / DOI:
doi:10.1002/hep.25582
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22234924
Print-ISSN:
0270-9139
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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