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Titel:

Genetic analyses of heme oxygenase 1 (HMOX1) in different forms of pancreatitis.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Weiß, S; Jesinghaus, M; Kovacs, P; Schleinitz, D; Schober, R; Ruffert, C; Herms, M; Wittenburg, H; Stumvoll, M; Blüher, M; Grützmann, R; Schulz, HU; Keim, V; Mössner, J; Bugert, P; Witt, H; Drenth, JP; Krohn, K; Rosendahl, J
Abstract:
Heme oxygenase 1 (HMOX1) is the rate limiting enzyme in heme degradation and a key regulator of inflammatory processes. In animal models the course of pancreatitis was ameliorated by up-regulation of HMOX1 expression. Additionally, carbon monoxide released during heme breakdown inhibited proliferation of pancreatic stellate cells and might thereby prevent the development of chronic pancreatitis (CP). Transcription of HMOX1 in humans is influenced by a GT-repeat located in the promoter. As such,...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2012
Band / Volume:
7
Heft / Issue:
5
Seitenangaben Beitrag:
e37981
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0037981
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22666428
Print-ISSN:
1932-6203
TUM Einrichtung:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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